Iron Acquisition by the Genus Mycobacterium [electronic resource] :History, Mechanisms, Role of Siderocalin, Anti-Tuberculosis Drug Development / edited by B. Rowe Byers.
Contributor(s): Byers, B. Rowe [editor.] | SpringerLink (Online service).Material type: BookSeries: SpringerBriefs in Molecular Science: Publisher: Heidelberg : Springer International Publishing : Imprint: Springer, 2013.Description: V, 92 p. 39 illus., 9 illus. in color. online resource.Content type: text Media type: computer Carrier type: online resourceISBN: 9783319003030.Subject(s): Life sciences | Inorganic chemistry | Bioorganic chemistry | Infectious diseases | Proteins | Microbiology | Life Sciences | Microbiology | Protein-Ligand Interactions | Inorganic Chemistry | Bioorganic Chemistry | Infectious DiseasesDDC classification: 579 Online resources: Click here to access online
A History of Iron Metabolism in the Mycobacteria -- Mycobacterial Iron Uptake Mechanisms -- Siderocalin Combats Mycobacterial Infections -- Design of Anti-TB Drugs Using the Iron Uptake Platform.
Iron Acquisition by the Genus Mycobacterium summarizes the early evidence for the necessity of iron in mycobacteria and the discovery of the mycobacterial siderophores mycobactin, carboxymycobactin, and exochelin. The structural characterization of the mycobacterial siderophores is described. The genes so far identified as essential for iron acquisition and maintenance of an infection by pathogenic mycobacteria are discussed. The potential role of siderocalin in iron gathering by M. tuberculosis is featured. Because new drugs for M. tuberculosis are needed, this brief also emphasizes the design of antibiotics that interfere with siderophore biosynthesis and the use of siderophore analogs and/or conjugates.